Stratifies NAFLD Patients And Diagnoses NASH and NASH cirrhosis

Diagnoses NASH and NASH cirrhosis with LIVERFASt™

LIVERFASt™ is a blood-based test that provides a complete liver assessment and diagnosis for fibrosis, cirrhosis, activity and steatosis from early to late NASH stages.

LIVERFASt™ Identifies NAFLD Among Patients With MetS

The median scores of LIVERFASt™ tests increase with the number of MetS factors.

LIVERFASt™ stratifies NAFLD according to fibrosis stage and activity and steatosis grades.

LIVERFASt™ performs similarly for patients with obesity and diabetes.

Reliable Results Compared To Elastography

LIVERFASt™ provides reliable results in patients with conditions where liver stiffness measurement by elastography could not:

  • Severe obesity (risk of failure of elastography)
  • Severe steatosis (risk of overestimation of liver stiffness)
  • Significant liver cytolysis upper than 3 times ULN (risk of overestimation of liver stiffness)

LIVERFASt™ Outperforms Other Standards Of Care

LIVERFASt™ provides higher accuracy for cirrhosis in both diabetic and non-diabetic patients:

For severe fibrosis and cirrhosis:

  • Performed comparably to elastography with better applicability and no failure​
  • Outperformed FIB-4 in the identification of cirrhosis and severe fibrosis in Type 2 Diabetes NAFLD patients.

For early fibrosis:

  • Better performance than elastography without bias from inflammatory activity and steatosis​.

For steatosis:

  • Better grading of steatosis than liver ultrasound and controlled attenuation parameter (CAP).

LIVERFASt™ Has Similar Accuracy To Transient Elastography For Cirrhosis Diagnosis But With Better Applicability

References
  • Chalassani N, et al. Hepatology. 2018 Jan;67:328-357.
  • Younossi ZM, et al. Hepatology. 2016;64:73–84.
  • Aravind A, et al. JILSA. 2020;12:31-49.
  • De Lédinghen V, et al. Hepatology 2020.72;1:906A
  • Raskin M, et al. Hepatology 2020.72;1:273A
  • Decraeckeer M. et al., Aliment Ther Pharmacol 2022
  • Cohn B, et al. Hepatology 2020.72;1:943A
  • De Ledinghen V, et al. J Hepatol 2021:#198 (abstract)
  • Ratziu V, et al. 2005 Jun;128:1898-906.
  • Diehl AM, et al. NEJM. 2017; 377: 2063-2072.
  • Wong RJ, et al. Gastroenterology. 2015;148: 547-55.