Is A First-Line NASH Diagnostic Test

A First-Line NASH Diagnostic Test
For Chronic Liver Disease

A Rapidly Growing Burden Of NAFLD/NASH

Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25%, and its burden continues to increase in parallel with the obesity epidemic and lack of systematic screening. NAFLD and NASH (Non-alcoholic steatohepatitis) are the hepatic manifestations of metabolic syndrome (MetS).
NASH is an asymptomatic progressive form of NAFLD that can lead to cirrhosis, primary liver cancer, and liver transplantation. The incidence of HCC is increasing by 3% per year due to obesity.

NASH is anticipated to become the primary indication for liver transplantation due to the combination of increasing obesity prevalence worldwide, the lack of noninvasive screening tests, and approved therapies.​​

Problems For Identifying NASH

  • Risks: 3/1000 complications and 3/10000 mortality rate.
  • Sampling and interpathologist variability and biases between pathologists.
  • Unsustainable to monitor the progression or regression of NASH.
  • Not practical for large scale screening.

LIVERFASt™ Helps Physicians And Patients In Fighting NASH

The only noninvasive blood test that can effectively stratify NAFLD and NASH, and provide guidance for the clinical management of patients.

Simple Scorings

LIVERFASt™ provides scoring and staging for the three lesions of NAFLD/NASH (fibrosis, activity, and steatosis).

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NAFLD Stratification

LIVERFASt™ stratifies the severity of NASH and provides granularity to monitor each liver lesion.

Simple Scorings

LIVERFASt™ provides scoring and staging for the three lesions of NAFLD/NASH (fibrosis, activity, and steatosis).

LIVERFASt™ Has Similar Accuracy To Transient Elastography For Cirrhosis Diagnosis But With Better Applicability

References
  • Chalassani N, et al. Hepatology. 2018 Jan;67:328-357.
  • Younossi ZM, et al. Hepatology. 2016;64:73–84.
  • Aravind A, et al. JILSA. 2020;12:31-49.
  • De Lédinghen V, et al. Hepatology 2020.72;1:906A
  • Raskin M, et al. Hepatology 2020.72;1:273A
  • Decraeckeer M. et al., Aliment Ther Pharmacol 2022
  • Cohn B, et al. Hepatology 2020.72;1:943A
  • De Ledinghen V, et al. J Hepatol 2021:#198 (abstract)
  • Ratziu V, et al. 2005 Jun;128:1898-906.
  • Diehl AM, et al. NEJM. 2017; 377: 2063-2072.
  • Wong RJ, et al. Gastroenterology. 2015;148: 547-55.

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